Distribution of hepatitis B virus DNA sequences in different peripheral blood mononuclear cell subsets in HBs antigen‐positive and negative patients
Identifieur interne : 000359 ( France/Analysis ); précédent : 000358; suivant : 000360Distribution of hepatitis B virus DNA sequences in different peripheral blood mononuclear cell subsets in HBs antigen‐positive and negative patients
Auteurs : Y. Calmus [France] ; P. Marcellin ; G. Beaurain [France] ; L. Chatenoud [France] ; C. Bréchot [France]Source :
- European Journal of Clinical Investigation [ 0014-2972 ] ; 1994-08.
Abstract
Abstract. Hepatitis B virus (HBV) DNA sequences have been detected in leucocytes from HBV‐infected individuals. The aim of this study was to assess the specificity of HBV for a special leucocyte subset in nine healthy chronic HBV carriers, nine HBs antigen‐positive patients with chronic active hepatitis, 16 HBs antigen‐negative haemophiliacs with HBc and/or HBs antibodies, and 10 patients with HBV‐related systemic necrotizing vasculitis. HBV‐DNA sequences were found by Southern blot hybridization in the leucocytes of 15 out of the 44 (34%) patients. The prevalence was not significantly different between the four groups. HBV‐DNA was found in the CD4+ cells (9/11) as well as in the CD8+ cells (4/11), B cells (4/12) and monocytes (2/12). In conclusion, leucocytes, and particularly CD4+ lymphocytes, are frequently infected by HBV in patients with HBV serum markers.
Url:
DOI: 10.1111/j.1365-2362.1994.tb01105.x
Affiliations:
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Bréchot</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:6A058E6E54C52F55494A68A43185E079B3D62F64</idno><date when="1994" year="1994">1994</date><idno type="doi">10.1111/j.1365-2362.1994.tb01105.x</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-WB4FV1P5-J/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000F47</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000F47</idno><idno type="wicri:Area/Istex/Curation">000F47</idno><idno type="wicri:Area/Istex/Checkpoint">001A96</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001A96</idno><idno type="wicri:doubleKey">0014-2972:1994:Calmus Y:distribution:of:hepatitis</idno><idno type="wicri:Area/Main/Merge">004522</idno><idno type="wicri:Area/Main/Curation">004459</idno><idno type="wicri:Area/Main/Exploration">004459</idno><idno type="wicri:Area/France/Extraction">000359</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Distribution of hepatitis B virus DNA sequences in different peripheral blood mononuclear cell subsets in HBs antigen‐positive and negative patients</title><author><name sortKey="Calmus, Y" sort="Calmus, Y" uniqKey="Calmus Y" first="Y." last="Calmus">Y. 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Beaurain</name><affiliation wicri:level="3"><country>France</country><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName><wicri:orgArea>‡Laboratoire d'Immunologie, Faculté de Médecine Necker</wicri:orgArea></affiliation></author><author><name sortKey="Chatenoud, L" sort="Chatenoud, L" uniqKey="Chatenoud L" first="L." last="Chatenoud">L. Chatenoud</name><affiliation wicri:level="3"><country>France</country><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName><wicri:orgArea>‡Laboratoire d'Immunologie, Faculté de Médecine Necker</wicri:orgArea></affiliation></author><author><name sortKey="Brechot, C" sort="Brechot, C" uniqKey="Brechot C" first="C." last="Bréchot">C. Bréchot</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>§INSERM U‐75, Faculté de Médecine Necker, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">European Journal of Clinical Investigation</title><title level="j" type="alt">EUROPEAN JOURNAL OF CLINICAL INVESTIGATION</title><idno type="ISSN">0014-2972</idno><idno type="eISSN">1365-2362</idno><imprint><biblScope unit="vol">24</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="548">548</biblScope><biblScope unit="page" to="552">552</biblScope><biblScope unit="page-count">5</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1994-08">1994-08</date></imprint><idno type="ISSN">0014-2972</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0014-2972</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract. Hepatitis B virus (HBV) DNA sequences have been detected in leucocytes from HBV‐infected individuals. The aim of this study was to assess the specificity of HBV for a special leucocyte subset in nine healthy chronic HBV carriers, nine HBs antigen‐positive patients with chronic active hepatitis, 16 HBs antigen‐negative haemophiliacs with HBc and/or HBs antibodies, and 10 patients with HBV‐related systemic necrotizing vasculitis. HBV‐DNA sequences were found by Southern blot hybridization in the leucocytes of 15 out of the 44 (34%) patients. The prevalence was not significantly different between the four groups. HBV‐DNA was found in the CD4+ cells (9/11) as well as in the CD8+ cells (4/11), B cells (4/12) and monocytes (2/12). In conclusion, leucocytes, and particularly CD4+ lymphocytes, are frequently infected by HBV in patients with HBV serum markers.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><noCountry><name sortKey="Marcellin, P" sort="Marcellin, P" uniqKey="Marcellin P" first="P." last="Marcellin">P. Marcellin</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Calmus, Y" sort="Calmus, Y" uniqKey="Calmus Y" first="Y." last="Calmus">Y. Calmus</name></region><name sortKey="Beaurain, G" sort="Beaurain, G" uniqKey="Beaurain G" first="G." last="Beaurain">G. Beaurain</name><name sortKey="Brechot, C" sort="Brechot, C" uniqKey="Brechot C" first="C." last="Bréchot">C. Bréchot</name><name sortKey="Calmus, Y" sort="Calmus, Y" uniqKey="Calmus Y" first="Y." last="Calmus">Y. Calmus</name><name sortKey="Chatenoud, L" sort="Chatenoud, L" uniqKey="Chatenoud L" first="L." last="Chatenoud">L. Chatenoud</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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